Crosstalk Between Macroautophagy and Chaperone-Mediated Autophagy: Implications for the Treatment of Neurological Diseases

Haijian Wu, Sheng Chen, Al-Baadani Ammar, Jie Xu, Qun Wu, Kum Pan, Jianmin Zhang, Yuan Hong
2014 Molecular Neurobiology  
Macroautophagy and chaperone-mediated autophagy (CMA) are two important subtypes of autophagy that play a critical role in cellular quality control under physiological and pathological conditions. Despite the marked differences between these two autophagic pathways, macroautophagy and CMA are intimately connected with each other during the autophagy-lysosomal degradation process, in particu l a r, i n t h e s e t t i n g o f n e u r o l o g i c a l i l l n e s s . Macroautophagy serves as a
more » ... up mechanism to removal of malfunctioning proteins (i.e., aberrant α-synuclein) from the cytoplasm when CMA is compromised, and vice versa. The molecular mechanisms underlying the conversation between macroautophagy and CMA are being clarified. Herein, we survey current overviews concentrating on the complex interactions between macroautophagy and CMA, and present therapeutic potentials through utilization and manipulation of macroautophagy-CMA crosstalk in the treatment of neurological diseases.
doi:10.1007/s12035-014-8933-0 pmid:25330936 pmcid:PMC4586010 fatcat:luto363e7rdq5jurd2od6m3hfu