Synthesis, characterization and antibacterial activity of various substituted oxadiazolylpyrazolinyl/isoxazolinylcoumarin derivatives

Hemlata Kaur, Sunil Kumar, Indu Singh, Ashok Kumar
2010 International Journal of Pharma Sciences and Research (IJPSR)   unpublished
A series of 7-un/substituted-2-spiro-[5-((1-acetyl-5-(substitutedphenyl)amino)-3-(1-acetyl-5-(substitutedphenyl)) pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (4a-4h) and 7-un/substituted-2-spiro-2-[(-5-(substitutedphenyl)amino-4-(5-(substitutedphenyl))pyazolin-3-yl)-1,3,4-oxadiazol-2-yl]coumarins (5a-5h) by the reaction of 7-un/substituted-2-spiro-(3-substitutedarylidinyl chalconyl)-5-(substitutedarylidinylaminochalconyl)-oxadiazol-2-yl)coumarins (3a-3h) with hydrazine hydrate and hydroxyl
more » ... ne respectively. All the newly synthesized compounds were screened for their antibacterial activity against K. pneumoniae, S. aureus, E. coli and B. sublitis and were compared with the standard drug ciprofloxacin. The most potent antibacterial compound of this series was 4g. Structure of all the compounds were established by the elemental (C, H, N) and spectral (IR, 1 H NMR and mass) analysis.