Landscape Mapping of Functional Proteins in Insulin Signal Transduction and Insulin Resistance: A Network-Based Protein-Protein Interaction Analysis

Chiranjib Chakraborty, Sanjiban S. Roy, Minna J. Hsu, Govindasamy Agoramoorthy, Timothy Ravasi
2011 PLoS ONE  
The type 2 diabetes has increased rapidly in recent years throughout the world. The insulin signal transduction mechanism gets disrupted sometimes and it's known as insulin-resistance. It is one of the primary causes associated with type-2 diabetes. The signaling mechanisms involved several proteins that include 7 major functional proteins such as INS, INSR, IRS1, IRS2, PIK3CA, Akt2, and GLUT4. Using these 7 principal proteins, multiple sequences alignment has been created. The scores between
more » ... quences also have been developed. We have constructed a phylogenetic tree and modified it with node and distance. Besides, we have generated sequence logos and ultimately developed the protein-protein interaction network. The small insulin signal transduction protein arrangement shows complex network between the functional proteins.
doi:10.1371/journal.pone.0016388 pmid:21305025 pmcid:PMC3031563 fatcat:yqpru6ss4fcglfqjcp2n4do5ae