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Synthesis, Characterization and Molecular Docking of Novel Quinoline and Pyridine Derivatives
2017
Oriental Journal of Chemistry
Preserved Fulltext
A new series of substituted quinoline and pyridine derivatives 6a-h are synthesized by the coupling of hydrazide derivatives 4a-b with substituted carboxylic acids 5a-c in the presence of N,N,N',N'-tetramethyl-o-(benzotriazol-1-yl) uranium tetrafluoroborate TBTU as a coupling agent and lutidine as a base. The newly synthesized compounds 6a-l is characterized by analytical NMR and mass spectral data. The newly synthesized compounds were subjected to molecular docking studies for the inhibition
doi:10.13005/ojc/330604
fatcat:brajizatnvbblmai2fp5msatzq