Hepatoid adenocarcinoma of the lung (HAL) is a rare type of lung cancer, with only 19 cases in English literature being reported. Its diagnosis is based on pathology and the standard treatment has not been established. Case report: We present a case of HAL. The patient was a 42-year old man with a primary complaint of dry cough. The chest computed tomography revealed a mass of the right lung with the diameter of the largest cross-section of 12.4 cm. The patient underwent surgery.

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... ical staining of the specimen showed the tumor was positive forα-fetoprotein, Hepatocyte and CK, CK18. Gene test showed no epidermal growth factor receptor (EGFR) mutation, anaplastic lymphoma kinase (ALK) rearrangement or receptor tyrosine kinase (ROS1) mutation. The patient was diagnosed as HAL, stage IIIB and then received postoperational chemotherapy of peme-trexed. However, brain metastases were found and the disease free survival was merely 3 months.