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Comments on "Applications of simulated annealing for the design of special digital filters"
1996
IEEE Transactions on Signal Processing
The energy distribution along the protein-protein interface is not homogenous; certain residues contribute more to the binding free energy, called 'hot spots'. Here, we present a web server, HotPoint, which predicts hot spots in protein interfaces using an empirical model. The empirical model incorporates a few simple rules consisting of occlusion from solvent and total knowledge-based pair potentials of residues. The prediction model is computationally efficient and achieves high accuracy of
doi:10.1109/78.492550
fatcat:74qoedd7hnd3rpxt4k54kvctfi