This study aimed to analyze the influence of the primary site of tumor location on off-pump coronary artery bypass grafting (OPCABG) surgery combined with concurrent tumor resection and to identify factors affecting long-term survival. Fifty-seven patients with coronary artery disease (CAD) and malignancy who underwent simultaneous surgery retrospectively were enrolled. The primary site of tumor locations and cancer stage were used as a basis for grouping. The long-term survival among the

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... ups was compared, and the risk factors related to survival were analyzed. The median follow-up period was 40 months. The 5-year cumulative survival rate of patients undergoing OPCABG and tumor resection was 74%. There was no significant difference in long-term survival among the four oncological location subgroups (P = 0.8), while significant difference was found among the two cancer stage subgroups (P = 0.0076). On univariable and multivariable Cox regression analysis, only cancer stage was an independent predictor of the long-term mortality rate (hazard ratio 5.42, P = 0.007). For patients with potentially curable cancer and surgically correctable CAD, the safety of simultaneous surgery is confident. The primary site of tumor location does not significantly affect the long-term survival of these patients. The long-term survival rate strongly correlates with tumor stage.