Clara cell secretory protein (CCSP) is expressed abundantly within and the presence of agranular endoplasmic reticulum (12). the conducting airway epithelium and is thought to have immuno-Using these criteria, three broad categories of secretory cells regulatory functions. Differences in the localization of CCSP behave been defined, including nonciliated bronchiolar (Clara) tween mouse and human airways led us to hypothesize that funccells, serous cells, and goblet cells; the latter two

more »

... ons EST W82219, referred to hereon as SCGB3A2, was deter-This work was supported by research grants: HL64888, ES08964, and HL70575. mined to be a distantly related member of the secretoglobin family member) were found to define distinct subsets of secre-sreynolds@server.ceoh.pitt.edu tory epithelial cells in conducting airways of the mouse and