Effect of felodipine in combined with irbesartan on the blood uric acid, serum adiponectin, and renal function in young males with essential hypertension

Jing Wang, Yan-Li Liu
2017 Journal of Hainan Medical University  
Objective: To explore the effect of felodipine in combined with irbesartan on the blood uric acid (UA), serum adiponectin (APN), and renal function in young males with essential hypertension (EH). Methods: A total of 134 young male patients with EH who were admitted in our hospital from January, 2016 to January, 2017 were included in the study and randomized into the observation group and the control group. The patients in the control group were given felodipine sustanined release tablets, 5
more » ... lease tablets, 5 mg/time, 1 time/d. On this basis, the patients in the observation group were given irbesartan, 150 mg/time, 1 time/d. To those whose blood pressure was not reduced under 140/90 mmHg after 4 week treatment, the dose of felodipine sustanined release tablets was increased to 10 mg/d. A maintenance dose was adopted according to the individual conditions until the ideal blood pressure reduction effect was achieved. The morning fasting venous blood was collected before treatment, 4 and 12 weeks after treatment in the two groups. ELISA was used to detect APN level. Uricase-peroxide enzymic method was used to detect UA level. The full automatic biochemical analyzer was used to detect BUN and Scr. Ccr was calculated. Urine was collected. RIA was used to detect 24 h Upro. The morning fasting venous blood before treatment, 24 and 48 weeks after treatment was collected. RIA was used to detect the serum T and SHBG levels. Results: Scr and 24 h Upro 4 and 12 weeks after treatment in the two groups were gradually reduced, while Ccr was gradually elevated. BUN 12 weeks after treatment in the observation group was significantly reduced. Scr and 24 h Upro 4 and 12 weeks after treatment in the observation group were significantly lower than those in the control group, while Ccr was significantly higher than that in the control group. BUNS 12 weeks after treatment in the observation group were significantly lower than those in the control group. T level 24 and 48 weeks after treatment in the two groups was significantly elevated, while SHBG afte [...]
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