RESPONSE OF HAART (HIGHLY ACTIVE ANTIRETROVIRAL THERAPY) ON CD4 COUNTS AND HAEMOGLOBIN IN PATIENTS WHO ACQUIRED HIV INFECTION BY HETEROSEXUAL AND BLOOD TRANSFUSION ROUTES
Journal of Evolution of Medical and Dental Sciences
BACKGROUND Dynamics of HIV acquired through the blood transfusion is studied largely, there are no studies that show the difference of impact of HAART on HIV acquired by heterosexual and blood transfusion routes. This study compares the impact of HAART between these groups. MATERIALS AND METHODS It is a descriptive comparative study. Data of HIV patients was collected from records and observed for eight years period. 39 PLHA who acquired HIV by blood transfusion and were alive on HAART as on
... e on HAART as on December 2012 were matched with 39 patients who acquired HIV by heterosexual route with age, sex and duration of ART were analysed. Data was analysed with CD4 raise and HB raise in both groups. RESULTS Total cases were 78. 39 patients who acquired HIV by transfusion and heterosexual route in each group were selected. 23 males and 16 females acquired HIV by transfusion route. 24 males and 15 females acquired HIV by heterosexual route. Mean age of both groups is 32.06 years. Mean duration of ART was 6.6 years for both groups. The mean raise in CD4 between two groups heterosexual and blood-transfusion was 440 and 544 respectively. The mean raise in HB between two groups heterosexual and blood-transfusion was 1.6 g% and 2.6 g% respectively. The CD4 raise was 20% more in transfusion-acquired HIV without statistical significance. The haemoglobin raise in transfusion-acquired HIV was 60% more than without statistical significance. Unpaired t-tests show females in transfusion group have statistically significant raise in HB. Unpaired t-tests show males in heterosexual group have statistically significant poor raise in CD4. CONCLUSION Response to HAART by patients who acquired HIV by blood transfusion was better than the patients who acquired HIV by heterosexual route. Differences in early stages of acute HIV infection and the differences in involvement of lymphatic tissues and reservoirs in transfusion-acquired HIV may be the reasons for better response to HAART.