Prediction of vitamin D deficiency by simple patient characteristics

Evelien Sohl, Martijn W Heymans, Renate T de Jongh, Martin den Heijer, Marjolein Visser, Thomas Merlijn, Paul Lips, Natasja M van Schoor
2014 American Journal of Clinical Nutrition  
Vitamin D status is currently diagnosed by measuring serum 25-hydroxyvitamin D [25(OH)D]. Objective: This study aimed to develop a risk profile that can be used to easily identify older individuals at high risk of vitamin D deficiency. Design: This study was performed within the Longitudinal Aging Study Amsterdam, an ongoing cohort study in a representative sample of the Dutch older population (n = 1509 for the development sample and n = 1100 for the validation sample). Prediction models for
more » ... um 25(OH)D concentrations ,50 and ,30 nmol/L were developed by using backward logistic regression. Risk scores were calculated by dividing the individual regression coefficients by the regression coefficient with the lowest b to create simple scores. Results: Serum 25(OH)D concentrations ,50 and ,30 nmol/L were present in 46.2% and 17.5% of participants, respectively. The model for the prediction of concentrations ,50 nmol/L consisted of 13 easily assessable predictors, whereas the model for concentrations ,30 nmol/L contained 10 predictors. The resulting areas under the curve (AUCs) were 0.78 and 0.80, respectively. The AUC in the external validation data set was 0.71 for the ,50-nmol/L model. At a cutoff of 58 in total risk score (range: 8-97), the model predicted concentrations ,50 nmol/L with a sensitivity of 61% and a specificity of 82%, whereas these values were 61% and 84%, respectively, at a cutoff of 110 in the total risk score (range: 6-204) in the model for concentrations ,30 nmol/L. Conclusions: Two total risk scores, including 13 or 10 predictors that can easily be assessed, were developed and are able to predict serum 25(OH)D concentrations ,50 and ,30 nmol/L accurately. These risk scores may be useful in clinical practice to identify persons at risk of vitamin D deficiency. Am J Clin Nutr 2014;99:1089-95.
doi:10.3945/ajcn.113.076430 pmid:24552751 fatcat:24y6tw7pcne5rlc7b23btzwmwa