The study was aimed at assessing the family characteristics and the relationship between family characteristics and objective as well as subjective quality of life among participants using single substance versus multiple substance users. The study is part of a comprehensive cross sectional descriptive study assessing 190 participants who consented to be studied. Each participant completed a family characteristic and subjective quality of life questionnaire along-side a World Health

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... Quality of Life-BREF questionnaire. All participants were interviewed with the Composite International Diagnostic Interview instrument to make a diagnosis of substance use disorder using ICD-10 diagnostic criteria. The data was analyzed using the Statistical Package for Social Sciences Version 20.0. The study found multiple substance users whose fathers had primary school education (p = 0.006) and had died (p = 0.027) had lower quality of life in their social relationship domain on World Health Organization Quality of Life. No statistical significant relationship was found between subjective quality of life and family characteristics of single versus multiple substance users. In conclusion only social relationship domain on World Health Organization Quality of Life was found to have statistically significant relationship in the study. All other domains on World Health Organization Quality of Life were not significantly associated with any family characteristic.