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CRISPR-SURF: Discovering regulatory elements by deconvolution of CRISPR tiling screen data
[article]
2018
bioRxiv
pre-print
Tiling screens using CRISPR-Cas technologies provide a powerful approach to map regulatory elements to phenotypes of interest, but computational methods that effectively model these experimental approaches for different CRISPR technologies are not readily available. Here we present CRISPR-SURF, a deconvolution framework to identify functional regulatory regions in the genome from data generated by CRISPR-Cas nuclease, CRISPR interference (CRISPRi), or CRISPR activation (CRISPRa) tiling screens.
doi:10.1101/345850
fatcat:ffn7ac4u3re4bbz3wk6z3gh5ie