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A Soft Sensor for Bioprocess Control Based on Sequential Filtering of Metabolic Heat Signals
2014
Sensors
Soft sensors are the combination of robust on-line sensor signals with mathematical models for deriving additional process information. Here, we apply this principle to a microbial recombinant protein production process in a bioreactor by exploiting bio-calorimetric methodology. Temperature sensor signals from the cooling system of the bioreactor were used for estimating the metabolic heat of the microbial culture and from that the specific growth rate and active biomass concentration were
doi:10.3390/s141017864
pmid:25264951
pmcid:PMC4239934
fatcat:ngaw7ev7sbepjibrndzvua2loy