Food and drugs analysis

1915 The Analyst  
11. (Estimation of Aconitine, Codeine, Cocaine, Morphine, and Strychnine.) J. W. Marden and V. Elliott. (J. Ind. and h'ng. Chem., 1914,6,928-934.) ( C' . ANALYST, 1914,39,354.)--Chloroform is a much better solvent for aconitine than is ether, which is recommended for the purpose by the U.S. Pharmacopoeia. Three extractions, each with 10 C.C. of chloroform, will extract more than 99-9 per cent, of the aconitine from 50 C.C. of an ammoniacal aqueous solution. Six similar washings with. ether are
more » ... gs with. ether are necessary to extract even 99 per cent. Chloroform is an even better solvent for codeine, two washings sufficing to remove practically 99-9 per cent., using the quantities stated above. For the extraction of codeine, ether is quite useless, the alkaloid being almost equally soluble in wet ether and in water saturated with ether. On the other hand, ether is nearly as good a solvent for cocaine as chloroform is for codeine, two washings sufficing to extract 99.8 per cent., using the quantities stated above. Two washings with chloroform will remove this percentage of strychnine from aqueous solution, whereas mixtures of ether and chloroform, recommended by many authors, are much less efficient. The difficulty in extracting morphine completely is discussed, and it is suggested that, if the distribution co-efficient for morphine between water or a saline solution and some immiscible solvent under closely defined conditions were accurately
doi:10.1039/an9154000011 fatcat:izmg6edmo5hp7cpv5wbhlag4xq