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Carcinogenicity and Acute Toxicity of Dimethylnitrosamine in Rainbow Trout (Salmo gairdneri)23
Journal of the National Cancer Institute
A dose related carcinogenic response was established for dimethylm'trosamine administered in the diet of rainbow trout (Salmo gairdneri). An equation was derived for the relationship between dose and hepatocellular carcinoma incidence. From a published dose response study using Porton rats as a test animal, a second equation was derived for comparison. The rat and the trout were approximately equivalent in their sensitivity to dimethylnitrosamine carcinogenesis. The histological nature of thedoi:10.1093/jnci/60.5.1127 pmid:205662 fatcat:xoayh6cwyvdcblcd4tou2puhmq