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Detecting and dissecting signaling crosstalk via the multilayer network integration of signaling and regulatory interactions
AbstractThe versatility of cellular response arises from the communication, or crosstalk, of signaling pathways in a complex network of signaling and transcriptional regulatory interactions. Understanding the various mechanisms underlying crosstalk on a global scale requires untargeted computational approaches. We present a network-based statistical approach, MuXTalk, that uses high-dimensional edges called multilinks to model the unique ways in which signaling and regulatory interactions candoi:10.1101/2022.09.29.510183 fatcat:n2gczqw7hfc7xjgaudhwppdawe