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Development and Application of the Strategy for the Quantitative Prediction of Drug-induced Parkinsomisms
Drug Metabolism and Pharmacokinetics
Drug-induced parkinsonism is generally known as a side effect of antipsychotic drugs. Recently, the induction of parkinsonism has been reported with the use of various peripherally acting drugs such as cal cium channel blockers, antiarrhythmic agents and so on. Therefore, it is eagerly required to quantitatively assess the extent of drug-induced parkinsonism prior to the dispensing of drugs. We have developed a strategy to quantitatively predict the intensity of drug-induced parkinsonism baseddoi:10.2133/dmpk.16.27 fatcat:wqb3cghqajh3tfzvg7ihd4lgem