The Potency of a Combined Diclofenac-Ampiclox against Streptococcus Pyogen Isolated from Patients with Pharyngitis: A pilot study

Rana Talib Al-Nafakh, Hussein Abdulkadhim, Naser A Naser
2019 Africa Health Research Organization  
Pharyngitis, scarlet fever, and rheumatic fever are of the major infectious problems caused by Streptococcus Pyogen. Emergence of antibiotic-resistant strains makes such infection, its rheumatic valvular disease, and glomerulonephritis complications a serious clinical challenge especially in children. Its aims and objectives are, in a maneuver of overcoming S. Pyogen resistance and improve its response to antibiotic, a no steroidal anti-inflammatory drug NSAID is repurposed as antimicrobial
more » ... s antimicrobial against S. Pyogen. In intention to be combined with the classical antibiotic recommended by WHO guideline of care, the combination was assessed for its MIC and combination index against S. Pyogen. There was a significant synergism between Ampiclox-diclofenac (index ˂ 1) at P= 0.012 and Z score= 2.3 further confirmation of MIC folds of dilutions are to be assessed to obtain reasonable evidence.
doi:10.36295/asro.2019.220414 fatcat:aycng7rq6fawzi4fhcsxmqro6y