Comparative analysis of clinical features of SARS-CoV-2 and adenovirus infection among children

Kuanrong Li, Ling Li, Xianfeng Wang, Hui Li, Jun Chen, Lei Liu, Jianbo Shao, Yi Xu, Liya He, Sitang Gong, Huimin Xia, Huiying Liang
2020 Virology Journal  
Background The new emerging coronavirus disease 2019 (COVID-19) overall shares similar symptoms with other common respiratory viral infections. We aimed in this study to compare COVID-19 and human adenovirus (HAdV) infections in pediatric patients regarding the frequencies of major clinical symptoms and the potential disparities in laboratory and imaging parameters. Methods Following a case–control-like design, we built 72 age-matched pediatric COVID-19 and HAdV patient pairs. Their early
more » ... ms and laboratory and imaging characteristics were then retrieved and compared. Results Fever and cough were the most common symptoms for both infections but were seen more often in HAdV than in COVID-19 patients (92% vs. 66% and 60% vs. 18%, respectively). Compared with COVID-19 patients, children with HAdV infection had statistically significantly higher values of neutrophil count, neutrophil percentage, activated partial thromboplastin time, prothrombin time, lactate dehydrogenase, C-reactive protein, procalcitonin but lower values of lymphocyte percentage, total bilirubin, potassium and sodium. Thoracic computed tomography also revealed more anomalies in HAdV patients than in COVID-19 patients (95% vs. 67%). Conclusions COVID-19 is an overall less symptomatic and less severe infection at admission compared to HAdV respiratory infection in pediatric population.
doi:10.1186/s12985-020-01461-4 pmid:33302983 fatcat:6j3s4i4qgnfspow4trs4rx4lae