MicroRNAs (miRNAs) are a class of small non-coding RNAs that regulate gene expression at both transcriptions and at post-transcriptional level. The present study was to investigate the pathogenic implications of miRNA in hepatocellular carcinoma (HCC) cells and further analyze its characteristics. We found that different expression profiles of miRNAs in tumor and adjacent tissue by miRNA microarray. MiR-134 expression was significantly decreased in human tumors and cancer cells. We demonstrate

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... hat miR-134 inhibits cancer cell proliferation, migration and induced apoptosis. Further, GSK3β was identified as a direct target of miR-134, and established the molecular and functional links between miR-134, GSK3β and migration in vitro. We also uncover the molecular pathways through regulating the AKT/GSK3β/SNAIL signaling pathway. Taken together, our findings provide a promising and potential therapeutic target for HCC.