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Antibody‐induced NKG2D blockade in a rat model of intraportal islet transplantation leads to a deleterious reaction
2020
Transplant International
Intraportal islet transplantation is plagued by an acute destruction of transplanted islets. Amongst the first responders, NK cells and macrophages harbor an activating receptor, NKG2D, recognizing ligands expressed by stressed cells. We aimed to determine whether islet NKG2D ligand expression increases with culture time, and to analyze the impact of antibody-induced NKG2D blockade in islet transplantation. NKG2D-ligand expression was analyzed in rat and human islets. Syngeneic marginal mass
doi:10.1111/tri.13589
pmid:32003082
fatcat:r4djkcsw45e6vnfe36p26cdaze