A personalized approach, taking into account the genotype and individual characteristics of the patient, provides great opportunities for more effective prevention, treatment and rehabilitation. The review is focused on the main directions of personalized medicine. Prospects for the development of personalized rehabilitative medicine, including the use of non-drug methods, are described. Studies showing the influence of physical factors on the genome are discussed. It has been shown that the

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... ects of physiotherapeutic factors are genetically determined. Advances in the field of physiogenetics indicate the need for developing and implementing personalized rehabilitative technologies.