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Association of nonfribrillar amyloid oligomers with drusen of aging and age-related macular degeneration
Protein misfolding and aggregation are thought to underlie the pathogenesis of many "amyloid diseases", such as Alzheimer and Parkinson diseases, whereby a stepwise protein misfolding process begins with the conversion of soluble protein monomers to prefibrillar oligomers and progresses to the formation of insoluble amyloid fibrils. Drusen are extracellular deposits found in eyes afflicted with age-related macular degeneration (AMD). Recent characterizations of drusen have revealed proteindoi:10.5282/edoc.5701 fatcat:vddpdyq4lnbpbor53uu2lqsiq4