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Cu-catalysed pyrazole synthesis in continuous flow
2016
Catalysis science & technology
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By using supported Cu(ii) catalysts for the regioselective synthesis of 1,4-disubstituted pyrazoles, we significantly reduced the Cu loading to 30 mol% and the alkyne required. Also, continuous flow allowed a dramatic reduction of reaction times going from 16 h to residence times of 5–15 min, being able to easily scale up this methodology.
doi:10.1039/c5cy02247a
fatcat:x3szqemfxbfqvloxurarwq2esm