Development of a simple, rapid and validated spectrophotometric method for nitazoxanide in pharmaceutical formulations and comparison with HPLC

Marcelo Donadel Malesuik, Clésio Soldatelli Paim, Elfrides Eva Scherman Schapoval, Martin Steppe
2010 Química Nova  
Recebido em 2/5/09; aceito em 25/9/09; publicado na web em 25/2/10 A rapid, economical, reproducible, and simple direct spectrophotometric method was developed and validated for the assay of nitazoxanide in pharmaceutical formulations. Nitazoxanide concentration was estimated in water at 345 nm and pH 4.5. The method was suitable and validated for specificity, linearity, precision, and accuracy. There was no interference of the excipients in the determination of the active pharmaceutical
more » ... armaceutical ingredient. The proposed method was successfully applied in the determination of nitazoxanide in coated tablets and in powders for oral suspension. This method was compared to a previously developed and validated method for liquid chromatography to the same drug. There was no significative difference between these methods for nitazoxanide quantitation.
doi:10.1590/s0100-40422010000300045 fatcat:6vqyfso44jfnnkrpgkbyz7ssma