Sickle cell disease is a common genetic disorder which represents major medical problem in certain parts of world. In India Chhattisgarh is one of the states in which sickle cell disease is common. Purpose of this study was to evaluate the patients of sickle cell disease with various surgical problems and their outcome. A prospective study of 100 patients with diagnosed sickle cell disease was done in the department of General Surgery of Pt. JNM medical college and attached hospital. Maximum

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... ients with surgical presentation were above 40 yrs. of age (48%) with male preponderance. Most common presenting symptom were generalized weakness and abdominal pain (69%). Important clinical sign was pallor 85%, splenomegaly 12%, vasoocclusive crisis in 53%, hemolytic crisis in 4% sequestration crisis in 5% and aplastic crisis seen in 1%. Various surgical presentations were acute appendicitis 14% cholelithiasis 15%, hollow viscous perforation 13% and various other presentations. 63 patients underwent surgical treatment and 37 were managed conservatively. Post operatively delayed wound healing was the common complication 52% due to wound infection 51%. Mortality was 5%. Although causes are multifactorial but patients of sickle cell disease are more prone to develop intra and post-operative complications so it is important for a surgeon to understand the pathophysiology and management of sickle cell disease to reduce the morbidity and mortality of these patients with surgical presentations.