Prevention of Deep-Vein-Thrombosis (DVT) in Hysterectomy Patients by Low-Dose-Heparin, Heparin-Dihydroergotamin and Acenocoumarol

S. Kunz, R. C. Briel
1979 VIIth International Congress on Thrombosis and Haemostasis   unpublished
In major gynecological surgery an incidence of 15 - 35% DVT is found. However there are no data concerning the incidence of DVT following hysterectomy, the most common operation in gynecology. Therefore, in 288 patients undergoing elective hysterectomy a 125-J-fibrinogen uptake test was carried out, starting 2 hours postop and repeated every 24 hours for 8 days. Results: Of the 97 patients who received heparin alone (2 x 5000 IU/24 h) 15, 5% developed DVT. In the heparin-dihydroergotamin group
more » ... droergotamin group (101 patients, 2 x 5000 IU heparin + 0 . 5 mg DHE) only 5, 9% positive scans were found (2p <0.05). In the acenocoumarol group (prophylaxis was begun 36 hrs. postop. in 90 patients) the frequency was 11.1%. Mean time for the onset in the heparin and heparin-DHE group was 4 and 3 days resp., in the acenocoumarol group 1 day. Duration of positive scans: 98, 53 and 50 hours. Localisation: 65 - 72 % calf-vein thrombosis;14 % bilateral in the heparin, 0 in the heparin-DHE and 9 % in the acenocoumarol group. No differences were registered in complications, side effects, blood volume insuction drainages, postop. fall of hemoglobin, standard morbidity and hematoma.
doi:10.1055/s-0039-1687247 fatcat:hjxsbay7bjfrpmul46m7g5zmwu