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Background A single injection of human umbilical mesenchymal stem cells (hUCMSCs) can improve dextran sulfate sodium (DSS)–induced acute colitis and decrease progression of acute to chronic colitis. We report the therapeutic efficacy of hUCMSCs in acute and chronic colitis-related testicular injury. Methods Male C57BL/6JNarl mice were divided into control, phosphate-buffered saline 1 (PBS1), PBS2, hUCMSCs 1 (SC1), and SC2 treated groups. Colitis were induced in the mice using 3% DSS. The micedoi:10.21203/rs.3.rs-270686/v1 fatcat:6v52y2ybsbdbfcfckh2eg7xn44