Diagnostic value of interferon-γ in the peripheral blood and the saliva of patients with oral lichen planus

Ranya Lotfi, Adel Imam, Mohamed El-Mofty, Maha Gareeb
2014 Journal of the Egyptian Women's Dermatologic Society  
The exact etiology of oral lichen planus (OLP) remains obscure. T helper 1 cellassociated cytokines and chemokines have been implicated in the pathogenesis. Among these cytokines, interferon-g (IFN-g) has been studied more extensively. Objective The purpose of this study was to measure the level of IFN-g in peripheral blood and whole unstimulated saliva (WUS) of OLP patients to assess their diagnostic value. Patients and methods IFN-g was measured simultaneously in serum and salivary (WUS)
more » ... es of 30 OLP patients and 30 healthy control individuals using enzyme-linked immunosorbent assay technique. Results A significantly higher mean IFN-g in the saliva was found among OLP cases compared with healthy control individuals, and the mean salivary IFN-g was significantly higher than that in the peripheral blood of cases. Conclusion IFN-g in WUS has a diagnostic value in OLP lesions. ROC Curve Receiver-operating characteristic (ROC) curve to define the best cut-off value of interferon-g (IFN-g) in the blood and the saliva to detect cases. 26 Journal of the Egyptian Women's Dermatologic Society
doi:10.1097/01.ewx.0000436701.29458.f3 fatcat:gheoaounsrdkvn56mm4ab6yj7a