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Curdlan Induces DC-Mediated Th17 Polarization via Jagged1 Activation in Human Dendritic Cells
Th17-inducing activity is carried by certain polysaccharides such as β-glucan derived from Candia albicans. Our previous studies have shown that Th1-and Th2-inducing activities can be qualitatively evaluated by the expression patterns of Notch ligand isoforms, using human monocyte-derived dendritic cells (Mo-DCs) and some leukemic cell lines such as THP-1. The association of Th17-inducing activities with Notch ligand expression patterns has been unclear. Methods: Mo-DCs from healthy volunteersdoi:10.2332/allergolint.09-oa-0103 pmid:20179419 fatcat:xna5hzurhjbyzbg35xfnegpwv4