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Ionizing Radiation Triggers Chromatin-bound kin17 Complex Formation in Human Cells
Journal of Biological Chemistry
The human DNA-binding HSA kin17 protein cross-reacts with antibodies raised against the stress-activated Escherichia coli RecA protein. We show here that HSA kin17 protein is directly associated with chromosomal DNA as judged by cross-linking experiments on living cells. We detected increased amounts of DNAbound HSA kin17 protein 24 h after ␥ irradiation, with 2.6-fold more HSA kin17 molecules after 6 Gy of irradiation (46,000 -117,000 molecules). At this time we observed that highlydoi:10.1074/jbc.m200321200 pmid:11880372 fatcat:oumcajov2feublccmycjqwakny