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A genome-wide CRISPR screen identifies regulators of beta cell function involved in type 2 diabetes risk
[article]
2021
bioRxiv
pre-print
Identification of the genes and processes mediating genetic association signals for complex disease represents a major challenge. Since many of the genetic signals for type 2 diabetes exert their effects through pancreatic islet-cell dysfunction, we performed a genome-wide pooled CRISPR loss-of-function screen in human pancreatic beta cells. We focused on the regulation of insulin content as a disease-relevant readout of beta cell function. We identified 580 genes influencing this phenotype:
doi:10.1101/2021.05.28.445984
fatcat:s2i7u3ooczem5mjxln5trevrh4