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Mutation and control of the human immunodeficiency virus
2008
Mathematical Biosciences
We examine the dynamics of infection by the human immunodeficiency virus (HIV), as well as therapies that minimize viral load, restore adaptive immunity, and use minimal dosage of anti-HIV drugs. Virtual therapies for wild-type infections are demonstrated; however, the HIV infection is never cured, requiring continued treatment to keep the condition in remission. With high viral turnover and mutation rates, drug-resistant strains of HIV evolve quickly. The ability of optimal therapy to contain
doi:10.1016/j.mbs.2008.03.002
pmid:18439629
fatcat:kvqhobzdcjgljcffi434e7paum