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Strontium ranelate promotes chondrogenesis through inhibition of the Wnt/β-catenin pathway
Stem Cell Research & Therapy
Cartilage regeneration is a key step in functional reconstruction for temporomandibular joint osteoarthritis (TMJ-OA) but is a difficult issue to address. Strontium ranelate (SrR) is an antiosteoporosis drug that has been proven to affect OA in recent years, but its effect on chondrogenesis and the underlying mechanism are still unclear. Bone mesenchymal stem cells (BMSCs) from Sprague-Dawley (SD) rats were induced in chondrogenic differentiation medium with or without SrR, XAV-939, and LiCl.doi:10.1186/s13287-021-02372-z pmid:34016181 fatcat:jq4mvtilpvfrlnq45qrxm4lvci