Anaplastic large cell lymphoma: a rare cause of extreme neutrophilia in a child

Gayathri Satish, Arathi Srinivasan, Shruti Varghese, Ravi Kumar, Bala Ramachandran, Julius Scott, Sarala Rajajee
2016 International Journal of Contemporary Pediatrics  
CASE REPORT A three year old boy was admitted to our hospital with history of high grade continuous fever of three weeks duration with no associated symptoms. He had been admitted in two other hospitals prior and had been administered multiple intravenous antibiotics. There was no significant past history. Examination revealed an ill looking child with pallor, icterus, presence of small cervical and axillary lymphadenopathy (1x1 cm), hepatosplenomegaly with polyserositis manifesting as moderate
more » ... festing as moderate ascites and bilateral pleural effusion. There was no rash or arthritis. Initial investigations included ABSTRACT Anaplastic large cell lymphoma (ALCL) in children can present with a broad spectrum of clinical manifestations which apart from nodal and extra nodal disease include paraneoplastic phenomena that can mimic an infection or inflammatory illness leading to delayed diagnosis. The following case report describes a child with prolonged fever, hepatosplenomegaly, polyserositis and extreme neutrophilia masquerading as an infection or inflammatory disorder for long before the definitive diagnosis of ALCL was made. This case highlights the rare paraneoplastic phenomena in ALCL and the heightened need to suspect this disorder when the search for underlying infections and connective tissue disorders are not conclusive.
doi:10.18203/2349-3291.ijcp20160182 fatcat:hpr6wkp7drcgjeepu4obt4ynvu