Research Progress in Epigenetics of Pancreatitis-cancer Transformation

YUE Ming, XU Haiyan, ZHANG Xiaofei, WANG Liwei
2021 Zhongliu Fangzhi Yanjiu  
Pancreatic ductal adenocarcinoma is one of the most common malignant tumors. Its early diagnosis and treatment are very difficult, and the mortality and recurrence rate are high. Chronic pancreatitis is an important risk factor for pancreatic cancer and has great potential to develop into pancreatic cancer. Therefore, it is necessary to study the mechanism of pancreatitis-cancer transformation for early diagnosis and treatment of pancreatic cancer. In recent years, more and more studies have
more » ... wn that epigenetic modification plays an important role in pancreatitis-cancer transformation, and can provide an effective target for the diagnosis and treatment of pancreatic cancer. This article summarizes the role and mechanism of epigenetics in pancreatitis-cancer transformation based on the current research progress.
doi:10.3971/j.issn.1000-8578.2021.20.0977 doaj:153352412b334c2981740c58a4c1e729 fatcat:zzb7jrskozbencrlsh4gwmb4fu