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Premature Chromatin Condensation Induced by Loss of RCC1 Is Inhibited by GTP- and GTPγS-Ran, but Not GDP-Ran
1996
Journal of Biological Chemistry
RCC1 is a guanine nucleotide exchanging factor acting on nuclear G protein Ran. Premature chromatin condensation occurs in the temperature-sensitive rcc1 ؊ mutant of the BHK21 cell line, tsBN2, at the restrictive temperature. This observation can be explained if the premature activation of MPF is normally inhibited by GTP-Ran. In the absence of RCC1, GDP-Ran predominates, resulting in MPF activation. However, experiments with Ran mutants to determine whether GTP-or GDP-Ran prevents activation
doi:10.1074/jbc.271.25.14665
pmid:8663347
fatcat:rrhmznvgfzcqljoduqv3iyb3ey