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AbstractThe blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain's metabolic activity as well as neuronal function. Thus, the functional and structural integrity of the BBB is pivotal to maintain the homeostasis of the brain microenvironment. The different cells and structures contributing to developing this barrier are summarized along with the different functions that BBB plays at the brain–blood interface. Wedoi:10.1186/s12987-020-00230-3 pmid:33208141 pmcid:PMC7672931 fatcat:wvzzgaveqzbxhdcfy7gq5htkru