Genome-Scale Oscillations in DNA Methylation during Exit from Pluripotency

Steffen Rulands, Heather J. Lee, Stephen J. Clark, Christof Angermueller, Sébastien A. Smallwood, Felix Krueger, Hisham Mohammed, Wendy Dean, Jennifer Nichols, Peter Rugg-Gunn, Gavin Kelsey, Oliver Stegle (+2 others)
2018 Cell Systems  
Highlights d Co-expression of DNMT3s and TETs promotes genomescale oscillations in DNA methylation d Oscillation amplitude is greatest at a CpG density characteristic of enhancers d Cell synchronization reveals oscillation period and link with primary transcripts d Multi-omic single-cell profiling provides evidence for oscillatory dynamics in vivo
doi:10.1016/j.cels.2018.06.012 pmid:30031774 pmcid:PMC6066359 fatcat:dmhkmfectbec3htvshvdzylaxq