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The role of individual integrins in human ␤-cell development and function is largely unknown. This study describes the contribution of ␣ v -integrins to human ␤-cell adhesion, spreading, and motility. Developmental differences in ␣ v -integrin utilization are addressed by comparing the responses of adult and fetal ␤-cells, and vitronectin is used as a substrate based on its unique pattern of expression in the developing pancreas. Fetal and adult ␤-cells attached equally to vitronectin anddoi:10.1074/jbc.m308425200 pmid:14766759 fatcat:tb22yhku4bgonfkdzvgka2lmbe