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MR1-restricted mucosal-associated invariant T (MAIT) cells play a unique role in the immune system. These cells develop intrathymically through a three-stage process, but the events that regulate this are largely unknown. Here, using bulk and single-cell RNA sequencing–based transcriptomic analysis in mice and humans, we studied the changing transcriptional landscape that accompanies transition through each stage. Many transcripts were sharply modulated during MAIT cell development, includingdoi:10.1126/sciimmunol.aay6039 pmid:31757835 pmcid:PMC10627559 fatcat:ygtwtmmxojastilo6ux2zjd2oy