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Influence of calcium channel blockers on anticonvulsant and antinociceptive activities of valproic acid in pentylenetetrazole-kindled mice
2012
Pharmacological Reports
Backgroud: Comorbidities of epilepsy comprise some pain disorders, including acute nociceptive pain, therefore, antiepileptic drugs can prove efficacy in the management of this kind of pain albeit with several adverse reactions. The current study aimed to evaluate the modulatory effects of calcium channel blockers on the anticonvulsant and antinociceptive effects of valproic acid (VPA) in pentylenetetrazole (PTZ)-kindled mice. Methods: Kindled mice were treated with 20 mg/kg (ip) of diltiazem,
doi:10.1016/s1734-1140(12)70769-7
pmid:22661180
fatcat:c7suzu3hfrhyxngwjhds3w553u