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Emergent Functional Network Effects in Parkinson Disease
2018
Cerebral Cortex
The hallmark pathology underlying Parkinson disease (PD) is progressive synucleinopathy, beginning in caudal brainstem that later spreads rostrally. However, the primarily subcortical pathology fails to account for the wide spectrum of clinical manifestations in PD. To reconcile these observations, resting-state functional connectivity (FC) can be used to examine dysfunction across distributed brain networks. We measured FC in a large, single-site study of nondemented PD (N = 107; OFF
doi:10.1093/cercor/bhy121
pmid:29878081
pmcid:PMC6519699
fatcat:nzlolxrqqzb2rei6uhrmgx3bte