Validation of Automated White Matter Hyperintensity Segmentation

Sean D. Smart, Michael J. Firbank, John T. O'Brien
2011 Journal of Aging Research  
Introduction. White matter hyperintensities (WMHs) are a common finding on MRI scans of older people and are associated with vascular disease. We compared 3 methods for automatically segmenting WMHs from MRI scans.Method. An operator manually segmented WMHs on MRI images from a 3T scanner. The scans were also segmented in a fully automated fashion by three different programmes. The voxel overlap between manual and automated segmentation was compared.Results. Between observer overlap ratio was
more » ... %. Using our previously described in-house software, we had overlap of 62.2%. We investigated the use of a modified version of SPM segmentation; however, this was not successful, with only 14% overlap.Discussion. Using our previously reported software, we demonstrated good segmentation of WMHs in a fully automated fashion.
doi:10.4061/2011/391783 pmid:21904678 pmcid:PMC3167190 fatcat:jf56r4x2z5gw7p3xezxxghfccy