Plasma Total Homocysteine Level and Bone Mineral Density

Clara Gram Gjesdal
2006 Archives of Internal Medicine  
Plasma total homocysteine (tHcy) has been associated with hip fracture but not directly with bone mineral density (BMD). We examined the association of hip BMD with levels of plasma tHcy, folate, and vitamin B 12 and the methylenetetrahydrofolate reductase (MTHFR) 677C→T and 1298A→C polymorphisms. Methods: Bone mineral density was measured between 1997 and 2000 in 2268 men and 3070 women, aged 47 to 50 and 71 to 75 years, from the Hordaland Homocysteine Study cohort. Low BMD was defined as BMD
more » ... n the lowest quintile for each sex and age group. Linear, logistic, and generalized additive regression models were used. Results: Plasma levels of tHcy were inversely related to BMD among middle-aged and elderly women (PϽ.001)
doi:10.1001/archinte.166.1.88 pmid:16401815 fatcat:6ec6z26kmvdnhat6uhgriym7au