Evaluating a new endovascular treatment for intracranial aneurysms must not only demonstrate short-term safety and efficacy, but also evaluate longer term outcomes (e. g., delayed complications, anatomical results, retreatment). The current analysis reports the 5-year clinical and anatomical results of WEB treatment in two European combined trial populations (WEBCAST [WEB Clinical Assessment of Intrasaccular Aneurysm Therapy]and WEBCAST-2). Methods All adverse events occurring during the

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... re and between the procedure and 5-year follow-up were independently evaluated by an expert. Aneurysm occlusion was evaluated by an independent core lab using a 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant. Results Both trials combined population initially included 106 patients aged 27 to 77 years. The 5-year follow-up visits were performed between 49 and 72 months after initial procedure. The safety and efficacy populations comprised 100 patients and 95 aneurysms, respectively. No adverse event related to the device occurred during the procedure and after the procedure during the 5-year follow-up period. Mortality at 5 years was 7.0% (7/100 patients) including mortality related the procedure (1/100, 1.0%) and other conditions (mostly cancer) (6/ 100, 6.0%). No mortality was related to the WEB. At 5 years, complete aneurysm occlusion and adequate occlusion were observed in 49/95 (51.6%) and 74/95 (77.9%) aneurysms, respectively. Conclusions This analysis conducted in a population of patients with complex-to-treat aneurysms (wide neck bifurcation aneurysms) confirms WEB's great safety profile and longterm stability of aneurysm occlusion.