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Management and prognosis of disease requires the accurate determination of specific biomarkers indicative of normal or disease-related biological processes or responses to therapy. Moreover since multiple determinations of biomarkers have demonstrated to provide more accurate information than individual determinations to assist the clinician in prognosis and diagnosis, the detection of several clinical biomarkers by using the same analytical device hold enormous potential for early detectiondoi:10.3390/s17050965 pmid:28448466 pmcid:PMC5464191 fatcat:rmuf63f3h5btvkocdzhnsubeni