The bite of Latrodectus tredecimguttatus, generally known as the Black Widow Spider (BWS), can cause a variety of symptoms, including muscular spasm, back pain, abdominal pain, severe sweating, and shivering. The bite brings weakness, too; however, quadriplegia has not been mentioned in the literature. Case Presentation: Here, we present a 42-year-old male with BWS bite who developed muscle weakness and paralysis in the four limbs. The patient needed mechanical ventilation. Nerve conduction

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... city showed myopathy in the patient. The patient could eventually walk after 45 days of supportive treatment. Conclusions: It can be hypothesized that quadriplegia may happen due to the vast acetylcholine depletion.