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Polarity and Specific Sequence Requirements of Peroxisome Proliferator-activated Receptor (PPAR)/Retinoid X Receptor Heterodimer Binding to DNA
1997
Journal of Biological Chemistry
The malic enzyme (ME) gene is a target for both thyroid hormone receptors and peroxisome proliferatoractivated receptors (PPAR). Within the ME promoter, two direct repeat (DR)-1-like elements, MEp and MEd, have been identified as putative PPAR response elements (PPRE). We demonstrate that only MEp and not MEd is able to bind PPAR/retinoid X receptor (RXR) heterodimers and mediate peroxisome proliferator signaling. Taking advantage of the close sequence resemblance of MEp and MEd, we have
doi:10.1074/jbc.272.32.20108
pmid:9242684
fatcat:u63o2dekiffulca5nhe3qp6u3i